Table 1.
Clinical and pathological findings at the start of initial treatments
| Combination Therapy (n = 40) | Heparin-Warfarin and Dipyridamole Therapy (n = 38) | P | |
|---|---|---|---|
| Gender (Men/Women) | 22/18 | 29/9 | 0.06 |
| Age at diagnosis (years) | 12.2 ± 3.0 | 11.6 ± 2.3 | 0.10 |
| Initial presentation (Chance/Gross hematuria) | 34/6 | 30/8 | 0.56 |
| Creatinine clearance (ml/min per 1.73 m2) | 144 ± 52 | 152 ± 47 | 0.35 |
| Serum albumin (g/dl) | 3.73 ± 0.65 | 3.94 ± 0.59 | 0.36 |
| Serum cholesterol (mg/dl) | 210 ± 116 | 194 ± 47 | 0.13 |
| Serum IgA (mg/dl) | 290 ± 115 | 276 ± 98 | 0.75 |
| Urinary protein excretion (g/1.73 m2/day) | 2.09 ± 1.78 | 1.35 ± 1.26 | 0.02 |
| Hematuriaa | 2.9 ± 0.8 | 2.6 ± 0.9 | 0.16 |
| Glomeruli | |||
| showing sclerosis (%) | 5.7 ± 8.6 | 4.1 ± 5.8 | 0.65 |
| showing crescents (%) | 23.6 ± 20.7 | 21.2 ± 17.9 | 0.68 |
| showing capsular adhesions (%) | 9.6 ± 10.0 | 7.0 ± 7.1 | 0.40 |
| showing mesangial proliferations (%) | 91.7 ± 7.4 | 90.2 ± 7.0 | 0.11 |
| Intensity of mesangial IgA depositsb | 2.2 ± 0.6 | 2.3 ± 0.5 | 0.72 |
The plus-minus values are the means ± SD.
a
Hematuria was quantified using dipsticks, and macrohematuria was quantified as 4.
b
The intensity of deposits on immunofluorescence microscopy was graded semiquantitatively on a scale from 0 to 3+: 0, no; 1+, slight; 2+, moderate; 3+, intense.