Table 2.
Clinical and pathological findings of at the end of initial 2-year treatments
| Combination Therapy (n = 40) | Heparin-Warfarin and Dipyridamole Therapy (n = 34) | P | |
|---|---|---|---|
| Creatinine clearance (ml/min per 1.73 m2) | 147 ± 33 | 145 ± 44 | 0.89 |
| Serum IgA (mg/dl) | 229 ± 87 | 281 ± 92 | 0.03 |
| Urinary protein excretion (g/1.73 m2 per day) | 0.28 ± 0.36 | 1.07 ± 1.57 | 0.01 |
| Patients with heavy proteinuria (≥1.0 g/1.73 m2 per day) | 2 (5.0%) | 10 (23.5%) | 0.009 |
| Patient without proteinuria (<0.2 g/1.73 m2 per day) | 20 (50.0%) | 6 (17.6%) | 0.007 |
| Hematuriaa | 0.5 ± 1.0 | 1.5 ± 1.1 | 0.0002 |
| Glomeruli | |||
| showing sclerosis (%) | 5.0 ± 6.9 | 16.4 ± 23.0 | 0.07 |
| showing crescents (%) | 0.4 ± 1.1 | 4.4 ± 10.3 | 0.16 |
| showing capsular adhesions (%) | 8.1 ± 11.2 | 6.4 ± 10.4 | 0.86 |
| showing mesangial proliferations (%) | 30.7 ± 26.7 | 57.5 ± 36.4 | 0.07 |
| Intensity of mesangial IgA depositsb | 1.3 ± 1.1 | 2.2 ± 0.6 | 0.02 |
The plus-minus values are the means ± SD.
a
Hematuria was quantified using dipsticks, and macrohematuria was quantified as 4.
b
The intensity of deposits on immunofluorescence microscopy was graded semiquantitatively on a scale from 0 to 3+: 0, no; 1+, slight; 2+, moderate; 3+, intense.