Table 1.
Baseline patient characteristics in subgroups defined by quartiles of LDL-C at baseline
| Quartile of LDL-C at Baseline | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Pa |
|---|---|---|---|---|---|
| n | 297 | 328 | 316 | 314 | |
| Range (mg/dl) | 36 to 103 | 104 to 122 | 123 to 144 | 145 to 269 | |
| Age (years) | 65.5 (8.8) | 66.8 (7.9) | 66.5 (8.2) | 66.3 (8.0) | 0.276 |
| Gender (males [%]) | 181 (61) | 190 (58) | 168 (53) | 138 (44) | <0.001 |
| Ever smoking (n [%]) | 174 (59) | 178 (54) | 188 (59) | 208 (66) | 0.323 |
| Body mass index (kg/m2) | 26.8 (4.6) | 27.3 (4.5) | 28.0 (5.1) | 28.2 (4.8) | 0.002 |
| Systolic BP (mmHg) | 148 (23) | 147 (23) | 144 (21) | 144 (21) | 0.028 |
| Diastolic BP (mmHg) | 76 (12) | 76 (11) | 75 (11) | 75 (11) | 0.181 |
| Ultrafiltration volume (kg) | 2.21 (1.15) | 2.13 (1.14) | 2.42 (1.24) | 2.25 (1.24) | 0.038 |
| Shunt (n [%]) | 41 (14) | 60 (18) | 52 (16) | 52 (16) | 0.018 |
| Time receiving dialysis (months) | 7.9 (6.7) | 8.4 (6.7) | 8.6 (7.3) | 8.0 (6.8) | 0.523 |
| Diuretics use (n [%]) | 238 (80.1) | 259 (79.0) | 251 (79.4) | 259 (82.5) | 0.690 |
| History ofb | |||||
| arrhythmia (n [%]) | 68 (21) | 62 (19) | 60 (19) | 46 (15) | 0.098 |
| myocardial infarction, CABG, PCI, CHDc (n [%]) | 83 (28) | 97 (30) | 101 (32) | 88 (28) | 0.721 |
| congestive heart failured (n [%]) | 107 (36) | 121 (37) | 121 (38) | 95 (30) | 0.282 |
| stroke or TIA (n [%]) | 44 (15) | 52 (16) | 60 (19) | 68 (22) | 0.182 |
| peripheral vascular disease (n [%]) | 129 (43) | 155 (47) | 145 (46) | 131 (42) | 0.015 |
| Hemoglobin (g/dl) | 11.0 (1.3) | 11.0 (1.4) | 10.7 (1.4) | 10.8 (1.2) | 0.004 |
| Hemoglobin A1ce (%) | 6.49 (1.20) | 6.75 (1.29) | 6.80 (1.25) | 6.84 (1.27) | 0.006 |
| Phosphate (mg/L) | 5.84 (1.45) | 6.12 (1.61) | 5.97 (1.70) | 6.22 (1.64) | 0.017 |
| Albumin (g/dl) | 3.88 (0.29) | 3.88 (0.26) | 3.73 (0.32) | 3.79 (0.31) | <0.001 |
| LDL-C (mg/dl) | 89.5 (11.1) | 113.3 (5.7) | 132.6 (6.2) | 165.4 (18.7) | – |
| HDL-cholesterol (mg/dl) | 34.2 (12.4) | 35.3 (14.4) | 36.8 (12.6) | 38.4 (12.9) | 0.006 |
| Triglycerides (mg/dl) | 255.1 (176.4) | 273.8 (187.7) | 260.2 (161.8) | 265.8 (136.8) | 0.471 |
| CRP (mg/L, median [25th to 75th percentile]) | 2.3 (1.2 to 3.5) | 2.3 (1.4 to 3.5) | 13.4 (7.6 to 23.6) | 11.6 (7.4 to 22.7) | 0.086 |
| NT-pro-BNP (ng/L, median [25th to 75th percentile]) | 3218 (1505 to 1264) | 3534 (1505 to 1291) | 3060 (1356 to 1743) | 3121 (1305 to 1947) | 0.392 |
Data shown are mean (standard deviation), if not otherwise mentioned. CABG, coronary artery bypass grafting surgery; PCI, percutaneous coronary intervention; CHD, coronary heart disease; TIA, transitory ischemic attack.
a
P-value for comparison of groups were derived from an analysis of covariance model (for continuous variables) or logistic regression model (for categorical variables), both adjusted for age and gender;
b
Types of disease and intervention are not mutually exclusive;
c
Documented by coronary angiography;
d
Predominantly New York Heart Association class II;
e
Glycated hemoglobin.