Table 4.
Incidence rate of leukocyte spike events by presence or absence of CKD
| Event | Annual Incidence Rate |
|||||
|---|---|---|---|---|---|---|
| Non-CKD (95% CI) | CKD (95% CI) | Unadjusted IRR (95% CI) | P for IRR | Adjusted IRR (95% CI) | P for IRR | |
| Total leukocyte count increase > 11.5 K/μl | 1.09 (0.93, 1.26) | 1.95 (1.78, 2.12) | 1.78 (1.50, 2.11) | <0.001 | 1.98 (1.63, 2.41) | <0.001 |
| Absolute granulocyte count increase > 8.6 K/μl | 0.81 (0.68, 0.95) | 1.43 (1.28, 1.58) | 1.76 (1.44, 2.14) | <0.001 | 2.08 (1.66, 2.62) | <0.001 |
| Absolute eosinophil count increase > 0.45 K/μl | 0.56 (0.45, 0.68) | 1.80 (1.63, 1.96) | 3.19 (2.55, 4.00) | <0.001 | 2.29 (1.79, 2.94) | <0.001 |
| Granulocyte (%) increase > 70% | 2.25 (2.02, 2.48) | 6.03 (5.73, 6.34) | 2.68 (2.39, 3.00) | <0.001 | 2.60 (2.29, 2.96) | <0.001 |
| Lymphocyte (%) decrease < 18% | 2.90 (2.64, 3.16) | 8.44 (8.08, 8.80) | 2.91 (2.64, 3.22) | <0.001 | 2.82 (2.53, 3.15) | <0.001 |
| Monocyte (%) increase > 11% | 2.09 (1.86, 2.31) | 5.86 (5.56, 6.16) | 2.81 (2.50, 3.16) | <0.001 | 2.68 (2.35, 3.06) | <0.001 |
| Eosinophil (%) increase > 3% | 1.14 (0.98, 1.31) | 3.12 (2.90, 3.34) | 2.73 (2.32, 3.20) | <0.001 | 2.08 (1.74, 2.49) | <0.001 |
| Basophil (%) increase > 2% | 0.54 (0.43, 0.65) | 1.31 (1.17, 1.45) | 2.43 (1.92, 3.08) | <0.001 | 2.07 (1.58, 2.71) | <0.001 |
Multivariate adjusted for age, gender, race, diabetes, smoking, ACEI or ARB use, statin use, and BP medication use. IRR, incidence rate ratio.