Table 3.
Vascular risk factors and renal variables dependent on clinical classes of albuminuria and eGFR
| Albuminuria (mg/24 h) |
eGFR (ml/min per 1.73 m2) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Low (<10) | Intermediate (10 to 29) | Elevated (≥30) | Pa | Low (<60) | Intermediate (60 to 89) | Normal (≥90) | Pb | |
| n | 2203 | 1296 | 596 | 344 | 2925 | 826 | ||
| Age (years), mean ± SD | 52 ± 11 | 55 ± 12 | 61 ± 12 | <0.001 | 65 ± 11 | 55 ± 11 | 50 ± 10 | <0.001 |
| Men (%) | 1010 (46) | 720 (56) | 410 (69) | <0.001 | 155 (45) | 1441 (49) | 544 (66) | <0.001 |
| Cardiovascular risk factors | ||||||||
| history of vascular events (%) | 117 (5) | 91 (7) | 100 (17) | <0.001 | 54 (16) | 213 (7) | 40 (5) | <0.001 |
| diabetes mellitus (%) | 68 (3) | 88 (7) | 99 (17) | <0.001 | 49 (14) | 162 (6) | 44 (5) | <0.001 |
| hypertension (%) | 500 (23) | 506 (39) | 383 (64) | <0.001 | 226 (66) | 946 (32) | 217 (26) | <0.001 |
| systolic BP (mmHg), mean ± SD | 121 ± 15 | 129 ± 17 | 138 ± 21 | <0.001 | 134 ± 21 | 125 ± 18 | 124 ± 16 | <0.001 |
| diastolic BP (mmHg), mean ± SD | 71 ± 8 | 75 ± 9 | 77 ± 9 | <0.001 | 75 ± 10 | 73 ± 9 | 72 ± 8 | <0.001 |
| body mass index (kg/m2), mean ± SD | 26 ± 4 | 27 ± 5 | 28 ± 5 | <0.001 | 28 ± 5 | 27 ± 4 | 26 ± 5 | <0.001 |
| overweight (%) | 1228 (56) | 874 (67) | 446 (75) | <0.001 | 259 (75) | 1838 (63) | 451 (55) | <0.001 |
| current smoking (%) | 502 (23) | 311 (24) | 159 (27) | 0.13 | 72 (21) | 632 (22) | 268 (33) | <0.001 |
| HDL cholesterol (mmol/L), mean ± SD | 1.5 ± 0.4 | 1.4 ± 0.4 | 1.3 ± 0.4 | <0.001 | 1.4 ± 0.4 | 1.4 ± 0.4 | 1.4 ± 0.4 | <0.001 |
| non–HDL cholesterol (mmol/L), mean ± SD | 5.4 ± 1.0 | 5.3 ± 1.0 | 5.2 ± 1.1 | 0.002 | 5.3 ± 1.2 | 5.4 ± 1.1 | 5.2 ± 1.0 | <0.001 |
| Renal variables | ||||||||
| eGFR MDRD (ml/min per 1.73 m2), mean ± SD | 79 ± 13 | 80 ± 15 | 74 ± 18 | <0.001 | 52 ± 8 | 76 ± 8 | 99 ± 7 | <0.001 |
| UAE (mg/24 h), median [IQR] | 7 [6 to 8] | 14 [12 to 20] | 64 [40 to 136] | <0.001 | 14 [7 to 47] | 9 [6 to 16] | 10 [7 to 16] | <0.001 |
a
P value for comparison between normal versus elevated albuminuria; P value for comparison between eGFR categories.