Table 5.

Sensitivity analyses of RFFT score with albuminuria in the youngest age tertile

Albuminuria (mg/24 h)	B	95% CI	P
General population samplea
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−1.4	−6.2 to 3.3	0.55
elevated (≥30)	−10.6	−19.9 to −1.3	0.02
Measurements of kidney function
eGFR CKD-EPI
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.08	−4.8 to 0.6	0.13
elevated (≥30)	−5.23	−10.4 to −0.04	0.04
creatinine clearance (24-hour urine collection)
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.26	−4.9 to 0.4	0.10
elevated (≥30)	−5.26	−10.5 to −0.05	0.04
Cockroft–Gault formula
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.45	−5.1 to 0.3	0.75
elevated (≥30)	−5.27	−10.4 to −0.09	0.04
Exclusion of comorbidities
after exclusion of diabetes mellitus
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−1.92	−4.6 to 0.8	0.13
elevated (≥30)	−6.04	−11.3 to −0.7	0.03
after exclusion of eGFR<60 ml/min per 1.73 m2
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.18	−4.9 to 0.5	0.15
elevated (≥30)	−5.77	−11.1 to −0.4	0.03
after exclusion of cardiovascular disease
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.14	−4.8 to 0.6	0.57
elevated (≥30)	−5.62	−10.9 to −0.3	0.04
after exclusion of cerebrovascular disease
low (<10)	Reference	Reference	Reference
intermediate (10 to 29)	−2.16	−4.9 to 0.5	0.13
elevated (≥30)	−5.13	−10.3 to −0.06	0.05

Model adjusted for adjusted for classes of albuminuria, eGFR, age, gender, educational level, diabetes, hypertension, history of cardiovascular disease, body mass index, alcohol use, cholesterol, and smoking. In the sensitivity analyses, no significant associations were found in the two older tertiles of age CKD-EPI, Chronic Kidney Disease-Epidemiology Collaboration.

^aSubsample PREVEND cohort reflecting the prevalence of elevated albuminuria in the normal population (7.5%).