Table 3.
Association of CKD with CVD based on serum creatinine and cystatin C estimates
| eGFR (ml/min per 1.73 m2) | CKD-Epi |
Cystatin C Three-variable Equation |
Cystatin C One-variable Equation |
||||||
|---|---|---|---|---|---|---|---|---|---|
| n (%) | Unadjusted Odds Ratio (95% CI) | Adjusted Odds Ratio (95% CI)a | n (%) | Unadjusted Odds Ratio (95% CI) | Adjusted Odds Ratio (95% CI)a | n (%) | Unadjusted Odds Ratio (95% CI) | Adjusted Odds Ratio (95% CI)a | |
| Piecewise linear analysis | |||||||||
| >60b | 501 (49) | 1.06 (0.89, 1.26) | 1.07 (0.88, 1.29) | 554 (54) | 0.98 (0.88, 1.11) | 0.98 (0.86, 1.11) | 689 (67) | 1.05 (0.96, 1.15) | 1.03 (0.93, 1.14) |
| <60b | 527 (51) | 1.35 (1.18, 1.55) | 1.31 (1.12, 1.53) | 474 (46) | 1.53 (1.33, 1.77) | 1.48 (1.25, 1.75) | 339 (33) | 1.55 (1.31, 1.83) | 1.49 (1.23, 1.81) |
| CKD 3 groups | |||||||||
| >60 | 501 (49) | 1.00 (ref) | 1.00 (ref) | 554 (54) | 1.00 (ref) | 1.00 (ref) | 689 (67) | 1.00 (ref) | 1.00 (ref) |
| 30 to 59 | 477 (46) | 1.45 (1.11, 1.88) | 1.40 (1.04, 1.87) | 433 (42) | 1.63 (1.26, 2.12) | 1.54 (1.15, 2.07) | 312 (30) | 2.12 (1.61, 2.78) | 2.00 (1.47, 2.72) |
| <30 | 50 (5) | 4.79 (2.55, 9.03) | 4.16 (2.03, 8.49) | 41 (4.0) | 6.60 (3.17, 13.76) | 5.68 (2.42,13.34) | 27 (3) | 5.03 (2.17, 11.67) | 4.25 (1.58, 1.46) |
| CKD 2 groups | |||||||||
| >60 | 501 (49) | 1.00 (ref) | 1.00 (ref) | 554 (54) | 1.00 (ref) | 1.00 (ref) | 689 (67) | 1.00 (ref) | 1.00 (ref) |
| <60 | 527 (51) | 1.62 (1.25, 2.08) | 1.53 (1.15, 2.03) | 474 (46) | 1.83 (1.42, 2.36) | 1.67 (1.25, 2.23) | 339 (33) | 2.26 (1.73, 2.95) | 2.09 (1.55, 2.83) |
ref, referent group.
a
Adjusted for age, gender, race, body mass index, smoking, diabetes, hypertension, systolic blood pressure, low density lipoprotein cholesterol, high density lipoprotein cholesterol, vitamin D, and log C-reactive protein. The sample sizes are based on the complete case data for all variables used in the multivariable models.
b
Values per 10 ml/min per 1.73 m2 lower eGFR.