Table 2.
GFR estimating equations in childrena
| GFR Estimating Equation | n | Ageb | GFRc | Creatinine/Cystatin C Assay Analyzer | GFR Measurement Method | |
|---|---|---|---|---|---|---|
| Serum creatinine based | ||||||
| bedside CKiD (23) | 41.3 [height/creatinine] | 349 | 1 to 16 | 41.3 (16 to 93) | Enzymatic [Advia 2400] | Iohexol |
| Counahan et al. (24) | 43 [height/creatinine] | 108 | 2 to 14d | 4 to 200 | Modified Jaffée [Technicon] | 51Cr-EDTA |
| Leger et al. (25) | 0.641 [weight/creatinine] + 16.063 [(height)2/creatinine] | 97 | 0.8 to 21 | 100 (31 to 200) | Kinetic Jaffé [Hitachi 911] | 51Cr-EDTA |
| Schwartz et al. (26, 27) | [55 × height]/creatinine; and [70 × height]/creatinine if boy ≥13 years | 186 | 0.5 to 20 | 125 (0 to 220) | Modified Jaffé [Technicon] | Inulin/creatinine clearance |
| Serum cystatin C based | ||||||
| Filler et al. (28) | 91.62 [1/cystatin C]1.123 | 536 | 1 to 18 | 103 (7 to 209) | Particle-enhanced nephelometric immunoassay (PENIA) [Behring BN ProSpec] | 99mTc-DTPA |
| Grubb et al. (29) | 84.69 [1/cystatin C]1.680; and 84.69 [1/cystatin C]1.680 × 1.384 if age <14 years | 536f | 0.3 to 93 | 63 (11 to 124)g; and 113 (37 to 240)h | Particle-enhanced turbidimetric immunoassay (PETIA) [Hitachi Modular P] | Iohexol |
| Serum creatinine and cystatin C based | ||||||
| Bouvet et al. (30) | 63.2 [1.2/cystatin C]0.56 × [1.09/creatinine]0.35 × [weight/45]0.3 × [age/14]0.4 | 100 | 1.4 to 22.8 | 95 (18 to 200) | Kinetic Jaffé (Olympus analyzer)/PENIA [BN-ProSpec] | 51Cr-EDTA |
| CKiD (23) | 39.1 [height/creatinine]0.516 × [1.8/cystatin C]0.294 × [30/BUN]0.169 × 1.099male × [height/1.4]0.188 | 349 | 1 to 16 | 41.3 (16 to 93) | Enzymatic [Advia 2400]/PETIA [DAKO] | Iohexol |
| Zappitelli et al. (31) | 43.82 [1/cystatin C]0.635 × [1/creatinine]0.547 × 1.35height | 103 | 2 to 18 | 74 ± 36 | Enzymatic [Vitros; Ortho-Clinical Diagnostics]/PENIA [Behring Nephelometer System] | Iothalamate |
BUN, blood urea nitrogen; 51Cr-EDTA, 51-cromium edetic acid; 99mTc-DTPA, 99mTc-diethylene-triamine-pentaacetic acid; CKiD, Chronic Kidney Disease in Children.
Height, m; weight, kg; creatinine, mg/dl; cystatin C, mg/L; BUN, mg/dl.
Age range, years.
GFR, ml/min per 1.73 m2 except Leger's and Bouvet's in ml/min: mean (range) presented for bedside CKiD, Leger, Filler, Bouvet, and CKiD; range presented for Counahan; median (range) presented for Schwartz; median (2.5th and 97.5th percentiles) presented for Grubb; mean ± SD presented for Zappitelli.
103 children and 5 adults.
Plasma creatinine value corrected to account for noncreatinine chromogens.
n = 85 for 0.3 to 17 year old category.
≥18 years old.
0.3 to 13 years old.