Figure 1.

Laboratory values at key time points in the course of the patient's aHUS episodes. (Upper) Laboratory and clinical parameters that would have played a role in establishing a clinical diagnosis of aHUS. Of note, the complement levels and platelet count were normal at the time of presentation of native kidney loss (October 1, 2006). The hemoglobin was the only assessed indication of possible hemolysis. The hemoglobin was low at the time of graft loss and this time was associated with a low platelet count (July 24, 2009). (Lower) The C3, C5, total complement pathway hemolytic assay, and platelet count at the time of the second transplant and perieculizumab use. The patient's baseline remission laboratory results are noted on the left of the figure for reference. HTN, hypertension; ARF, acute renal failure; TPE, therapeutic plasma exchange; h, hemoglobin (g/dl).