. 2011 Jan 26;2(4):316–319. doi: 10.1021/ml100308d

Table 1. Initial Alkoxydioxolane Synthesis and Bioassay.

graphic file with name ml-2010-00308d_0006.jpg

subs	R₁	R	dioxolane (yield)	IC₅₀ NF54 (nM)^a
1a	Me	Bu	4 (51%)	>10000
1a	Me	1-AdCH₂	5 (65%)	290
3a	Bu	Propyl	6 (64%)	>4000
3a	Bu	AdCH₂^b	7 (62%)	140
3a	Bu	Ph(CH₂)₂	8 (80%)	76
artesunate				2.5
chloroquine				11

See refs (26) and (101).

Ad = 1-adamantyl.