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. 2011 Mar 31;20(13):2495–2509. doi: 10.1093/hmg/ddr139

Figure 1.

Figure 1.

Immunoblotting analysis of mitochondrial fission, fusion and matrix proteins in early, definite and severe AD patients. Drp1 levels were significantly increased in AD patients at Braak stages I and II (P < 0.005), III and IV (P < 0.02) and V and VI (P < 0.002) compared with the Drp1 levels in control subjects. Fis1 protein levels were also significantly increased [Braak stages I and II (P < 0.003), III and IV (P < 0.01) and IV and V (P < 0.01)] relative to the control subjects. Fusion proteins: in contrast to fission proteins, mitochondrial fusion proteins were significantly decreased in AD patients relative to fission proteins in control subjects. Tomm40 levels were significantly decreased in AD patients at Braak stages IV and V (P < 0.004) relative to the controls. Matrix protein: CypD was significantly increased in AD patients at Braak stages III and IV (P < 0.04) and IV and V (P < 0.02) compared with controls. *Statistical significance at P < 0.05; **statistical significance at P < 0.005.