Figure 1.

Doxycycline treatment improved the motor behavior of Lama2^−/− mice. Exploratory behavior, measured by the number of times the mice stood up on their hind limbs during the first 5 min in a new cage, was, as indicated, significantly decreased in 4-week-old Lama2^−/− mice (center, n= 12) compared with wild-type mice (WT, leftmost, n= 16); and doxycycline treatment significantly increased the motor behavior of Lama2^−/− mice (rightmost, n= 17). Each dot represents a measurement from a different mouse; the boxes show the range of measurements; the horizontal bars are the average values; and error bars = SE. Note that 3 of the 17 doxycycline-treated Lama2^−/− mice did not appear to show improved motor behavior. See text for discussion. *P < 0.05; **P < 0.01.