Transfected HeLa cells |
[Ca2+]i increase |
10 μM |
Blocks S1P3 receptors |
No effect on S1P1-Hela |
|
Koide et al. (2002) |
Endothelial cells |
Expression of adhesion molecules |
1–10 μM |
S1P3 receptors modulate adhesion molecule expression |
Antisense oligonucleotides |
|
Kimura et al. (2006) |
Pancreatic Islet β Cells |
Cell survival |
10 μM |
S1P3 receptors mediate protective effects on β-cells against cytokine-induced apoptosis. |
None |
|
Laychock et al. (2006) |
B lymphocytes |
Rap1 activation |
10 μM |
S1P3 receptors activate Rap1 and might promote B-cell adhesion and migration |
None |
|
Durand et al. (2006) |
Transfected CHO cells |
[Ca2+]i increase
|
10 μM |
BML-241 is not selective |
|
|
Jongsma et al. (2006) |
Astrocytes |
Cell migration |
10 μM |
No role of S1P3
|
none |
|
Sato et al. (2007) |
Fibroblast-like synoviocytes |
Cell migration Cytokine/chemokine secretion Cell survival |
5 μM |
S1P stimulates FLS migration through S1P1 and S1P3, induces cytokine/chemokine secretion through S1P2 and S1P3, and protects from cell apoptosis via S1P1. |
None |
|
Zhao et al. (2008) |
Multiple myeloma cells |
Cell survival |
10 μM |
S1P3 receptors mediate S1P-induced STAT3 phosphorylation and Mcl-1 upregulation |
None |
|
Li et al. (2008b) |
Keratinocytes |
[Ca2+]i increase |
50 μM |
S1P3 receptors mediate [Ca2+]i increase |
No effect of SEW2871 (S1P1 agonist), inhibition by VPC23019
|
Specificity of SEW2871 and VPC23019 non-fully characterized |
Lichte et al. (2008) |
Transfected HEK-293 cells |
[Ca2+]i increase |
50 μM |
S1P3 receptors mediate [Ca2+]i increase |
No effect of SEW2871 (S1P1 agonist), inhibition by VPC23019
|
Specificity of SEW2871 and VPC23019 non-fully characterized |
Lichte et al. (2008) |
Mouse cardiomyocytes |
Erk activation |
0.1–10 μM |
No role of S1P3
|
none |
|
Tao et al. (2009) |
B35 neuroblastoma cells |
Cell migration |
10 μM |
No role of S1P3
|
No effect with other S1P3 antagonists (VPC23019, VPC25239) |
|
Hans et al. (2009) |
Embryonic stem cells |
Erk activation |
1–10 μM |
S1P5, not S1P3, activate Erk1/2 |
None |
|
Rodgers et al. (2009) |
Tango EDG3 cell lines |
GPCR β-arrestin recruitment and deactivation |
1 nM–0.1 mM |
The EDG3 response to S1P is inhibited by CAY-10444 with an IC50 of 4.6 μM |
None |
|
Wetter et al. (2009) |
Bronchial smooth muscle |
Contractility |
10 μM |
No role of S1P3
|
none |
|
Chiba et al. (2010) |
Granulosa lutein cells |
Cell migration |
1 μM |
S1P3 receptors are involved in FF-HDL- and S1P-stimulated granulosa cell migration |
Effect of suramin |
Suramin is non-specific |
Becker et al. (2010) |
Mouse cardiomyocytes |
Cell viability |
10 μM |
S1P3 receptors play a role in Akt activation and cardiomyocyte viability |
none |
|
Tao et al. (2010) |
Coronary artery |
Vasorelaxation |
10 μM |
S1P3 receptors mediate endothelium dependent coronary relaxation |
No effect of W146 (S1P1 antagonist), but inhibition by VPC23019 (mixed S1P1/S1P3 antagonist) |
Specificity of VPC23019 not fully characterized |
Mair et al. (2010) |
Immature B lymphocytes |
Cell migration |
100 μM |
S1P3 receptors are responsible for immature B-cell chemotaxis to S1P |
immature B-cells unable to migrate to S1P |
|
Donovan et al. (2010) |
Estrogen receptor-positive breast cancer cells |
Cell migration |
10 μM |
S1P3 stimulates the accumulation of phosphor-ERK-1/2 and promotes cell migration |
siRNA knockdown |
|
Long et al. (2010) |
Ovarian cancer cells |
Cell proliferation and survival |
1 μM |
S1P3 receptors do not play a role in cell proliferation and survival |
None |
|
Illuzzi et al. (2010) |
Mesenteric venules |
Microvessel permeability |
10 μM |
S1P3 receptors do not play a role in the protection by S1P of PAF-induced permeability |
None |
|
Zhang et al. (2010) |