Table 1. Regions of extreme sharing identified by SGS.
Chomosome numbers | Position (MB) (NCBI b36/hg18) | Size (cM) | Methods | Genes in the region | |
---|---|---|---|---|---|
CEU | |||||
Chr 1 | 35.449 | 35.717 | 0.075 | iHS, CLR, XP-EHH | ZMYM4, KIAA0319 L |
Chr 1 | 143.67 | 143.841 | 0.485 | novel | PDE4DIP, SEC22B |
Chr 5 | 109.638 | 110.131 | 0.115 | CLR, XP-EHH, CMS | TMEM232, SLC25A46 |
Chr 7 | 151.348 | 151.774 | 0.132 | XP-EHH | GALNT11, MLL3, FABP5P3 |
Chr 10 | 74.416 | 75.139 | 0.138 | CLR, CMS | P4HA1, ECD, NUDT13, FAM149B1, MRPS16, TTC18, ANXA7, ZMYND17, PPP3CB, SYNP02L, AGAP5 |
Chr 18 | 64.802 | 64.963 | 0.186 | CLR, XP-EHH | CCDC102B |
Chr 21 | 10.024 | 13.458 | 0.6 | XP-EHH | BAGE2, BAGE |
YRI | |||||
Chr 1 | 143.67 | 143.755 | 0.219 | novel | PDE4DIP |
Chr 21 | 0.019 | 0.064 | 0.637 | novel | TPTE, BAGE2, BAGE |
ASN | |||||
Chr 1 | 92.605 | 92.94 | 0.091 | iHS | RPAP2, GFI1, EVI5 |
Chr 1 | 103.215 | 103.416 | 0.079 | iHS, CLR | COL11A1 |
Chr 2 | 17.421 | 17.897 | 0.149 | XP-EHH | VSNL1, SMC6, GEN1 |
Chr 2 | 72.211 | 73.016 | 0.278 | CLR, XP-EHH | CYP26B1, EXOC6B, SPR, EMX1 |
Chr 2 | 177.337 | 177.599 | 0.217 | XP-EHH | |
Chr 3 | 25.905 | 26.376 | 0.386 | iHS, XP-EHH | |
Chr 3 | 48.665 | 49.708 | 0.04 | CLR | CELSR3, PRKAR2A, NCKIPSD, IP6K2, SLC25A20, P4HTM, WDR6, DALRD3, NDUFAF3 IMPDH2, QRICH1, QARS LAMB2, CCDC71, KLHDC8B, CCDC36, USP4, GPX1, RHOA AMT, TCTA, DAG1, APEH, BSN MST1, RNF123 |
Chr 5 | 117.375 | 117.697 | 0.183 | CLR, XP-EHH | |
Chr 7 | 142.266 | 142.397 | 0.192 | novel | EPHB6, TRPV6, TRPV5, KEL |
Chr 15 | 61.568 | 62.069 | 0.339 | CLR, XP-EHH | USP3, FBXL22, HERC1, DAPK2 |
Chr 18 | 30.411 | 30.602 | 0.172 | CLR | DTNA |
The iHS result is from the study of Voight et al4 and HapMap II.15 The CLR result is from the study of Williamson et al10 and Pickrell et al6 The XP-EHH result is from the study of Sabeti et al12 and Pickrell et al6 The CMS result is from the study of Grossman et al.13
All of regions are identified in the same population as in the cited literature. The underlined genes have previously been identified to be associated with human disease or trait. The genomic positions are according to NCBI Build 36/UCSC hg18. The centimorgan distance was calculated based on HapMap provided recombination rate and distance.