Table 2. Association of SNPs near TERC and leukocyte telomere length.
Major allele | HWE | Genotype distribution | Additive model | Dominant model | Recessive model | ||||
---|---|---|---|---|---|---|---|---|---|
SNP | (frequency) | P-value | (RR/RC/CC) | β | P-value* | β | P-value* | β | P-value* |
rs12696304 | G(0.68) | 0.83 | 398/1731/1853 | −0.02 | 4.5E-03 | −0.04 | 3.4E-02 | −0.03 | 1.4E-02 |
rs16847897 | C(0.61) | 0.78 | 600/1884/1452 | −0.03 | 9.6E-05 | −0.05 | 3.3E-03 | −0.04 | 7.4E-04 |
Abbreviations: CC, homozygous for major allele (common allele); HWE, Hardy–Weinberg equilibrium; RC, heterozygous for minor and major allele; RR, homozygous for minor allele (rare allele)
P-values were calculated in multiple regression model adjusted for age, gender and status of type 2 diabetes.