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A2E/isoA2E content in mouse eyes at 6 and 12+ months time points. KO, untreated Abca4−/− mice; mock, Abca4−/− animals injected with equine infectious anemia virus (EIAV)-null virus; CMV, Abca4−/− mice treated with EIAV-CMV-ABCA4 construct; Rho, Abca4−/− mice treated with EIAV-Rho-ABCA4 constructs; wt, wild type animals. Each bar (data point) represents n = 4–20 eyes with s.d. values shown.
