FIG. 1.

A divergent-eye stereo view of the DJ-1 dimer. A ribbon diagram of dimeric DJ-1 is shown with the molecular twofold axis perpendicular to the plane of the page. One monomer is shown in gold and the other in blue. The three cysteine residues in DJ-1 are shown in stick representation, although Cys46 is partially obscured in this view. Cys106 resides at the bottom of a prominent surface grove and is situated at the sharp turn between a strand and helix that is called the “nucleophile elbow.” Cys106 is the only functionally essential cysteine residue in DJ-1. C, carboxy terminus; N, amino terminus.