FIG. 2.

Sequence alignment of representative sulfiredoxins. Murine, Drosophila, Arabidopsis, Nostoc species PCC7120 (a cyanobacterium), and S. cerevisiae Srxs show 91%, 60%, 43%, 41%, and 33% sequence identity to human Srx, respectively. The secondary structural elements for hSrx are shown above the alignment: α, α-helices; β, β-strands; η, 3₁₀ helices. The residues highlighted by the red background and white lettering are strictly conserved. Residues that are either conserved in the majority of the proteins or have conservative substitutions are boxed in blue and colored red. The black dots above the alignment indicate every tenth residue of human Srx. (To see this illustration in color the reader is referred to the web version of this article at www.liebertonline.com/ars).