Table 7.
Secondary outcomes continued: neuroimaging
| Outcome | Measure | Description |
|---|---|---|
| Structural MRI: T1-weighted Whole Brain Measures |
1. Voxel Based Morphometry | A combination of different software packages will be used for automated and semi-automated computational neuroanatomical analyses, in addition to expert manual tracing of hippocampus and entorhinal cortex. |
| 2. Cortical thickness | ||
| 3. Whole brain volume | ||
| 4. GM volume | ||
| 5. WM volume | ||
| 6. CSF volume | ||
| Regional Measures | 1. Automated regional cortical volume measures | |
| 2. Manually traced subcortical volumes | ||
| FLAIR-weighted MRI | White matter hyperintensity volume | Automated measure of white matter disease load |
| Magnetic Resonance Spectroscopy (MRS) Relative measures of : |
1. N-acetylaspartate (NAA) | Measures of different brain metabolites using MR spectroscopy in the hippocampus and posterior cingulate grey matter. |
| 2. Cholines | ||
| 3. Myo-inositol | ||
| 4. Creatine+Phosphocreatine | ||
| Resting State functional MRI | 1. Bilateral hippocampal connectivity | Seed-based correlational analysis and Independent Component Analysis will be used to characterise individuals' resting state BOLD time series. |
| 2. Hippocampus functional connectivity map | ||
| 3. Posterior cingulate functional connectivity map | ||
| 4. Default Mode Network (DMN) | ||
| 5. DMN-anticorrelations | ||