Table 3.

Patient overall survival (OS) after colon cancer recurrence^*

		OS
Site of tumor recurrence	No. of patients	5-y rate (95% CI)	HR (95% CI)	P
				Overall <.001†
Local (reference)	45	22.7 (13.2 to 39.2)	—
Intra-abdominal	144	12.2 (7.7 to 19.3)	1.72 (1.16 to 2.54)	.007‡
Distant	429	7.8 (5.4 to 11.1)	1.79 (1.25 to 2.55)	.001‡
Liver	226	6.2 (3.7 to 10.6)	1.91 (1.32 to 2.76)	<.001‡
Lung	94	7.4 (2.8 to 19.4)	1.33 (0.89 to 1.99)	.168‡
Liver and lung	23	0.0 (0.0 to 0.0)	3.55 (2.04 to 6.17)	<.001‡
Other distant	86	12.1 (6.7 to 21.9)	1.98 (1.31 to 2.99)	.001‡

^*Impact of the site of tumor recurrence on OS after colon cancer recurrence was determined using a landmark analysis. A Cox model, stratified by study, was used to estimate the effect for each site of tumor recurrence. CI = confidence interval; HR = hazard ratio.

^†P value was calculated using a two-sided score test.

^‡P values were calculated using a two-sided Wald χ² test.