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. 2011 Jun 7;6(6):e20567. doi: 10.1371/journal.pone.0020567

Figure 2. Antidepressant drugs activate the immaturely glycosylated form of TrkB.

Figure 2

A) Acute imipramine treatment induces the phosphorylation (Y816) of full-length and low-molecular weight (LMW; ∼105 kDa) TrkB receptors in mouse brain. n = 6/group. B) Antidepressant-induced ∼105 kDa protein is sensitive to Endo-H digestion. A representative blot of triplicate data. C) Total TrkB, phosphorylated TrkB (Y816) and phosphorylated ∼105 kDa protein levels are increased in the brains of mice over-expressing catalytic TrkB receptors. n = 5/group. Data is presented as percentage of control ± standard error of mean (SEM). *<0.05, ***0.005; unpaired two-tailed t-test.