Figure 3. Role of BDNF in antidepressant-induced rapid TrkB activation in brain.
Imipramine (30 mg/kg, 30 min, i.p.) readily increases the phosphorylation of TrkB receptors (Y816) in forebrain specific BDNF−/− knock-out mice (BDNF2L/2LCk-cre) n = 4/group. Data is presented as percentage of control ± standard error of mean (SEM). *<0.05; unpaired two-tailed t-test.