Figure 5.

Chemical synthetic lethality induced by nucleoside analog inhibitors of IMPDH. Clone 12 cells were grown in microplates in the presence of mizoribine (A) or ribavirin (B) for a period of 3 wk before measurement of fluorescent ratio. Values for the fluorescent ratios are shown on the left. Rows A–H, in each matrix, represent the inhibitory drug data. Guanine was at 400 μM in column 1, and serial dilutions were in the indicated direction. In (A), mizoribine was at 400 μg/mL in row A and serial dilutions were in the indicated direction. In (B), ribavirin was at 200 μg/mL in row A and serial dilutions were in the indicated direction.