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. 2011 Jun 7;6(6):e20928. doi: 10.1371/journal.pone.0020928

Figure 1. Ribbon diagram and schematic representation of the flagellin-HA globular head fusion vaccine candidates.

Figure 1

HA globular head and flagellin structures are shown in green and orange, respectively. (A) HA monomer with encircled HA globular head; the HA globular head (HA1: amino acids 63–285) was genetically fused to the hypervariable region to replace domain 3 of flagellin (STF2R3.HA1, B), the C-terminus (STF2.HA1, C), or both positions (STF2R3.2xHA1, D). (E) linear schematic representation of recombinant flegallin-HA1 fusion proteins: Indicated are the flagellin domains D0 (black), D1 (blue), D2 (green), and D3 (red) as well as HA1 (open box) of Influenza A/California/07/2009. Beginning amino acid numbers of each domain are given.