Table 1.

Association between SNPs in SIRT1 and diabetic nephropathy

	Allele frequencies (nephropathy case−control)
	Proteinuria				ESRD	Combined
	Study 1	Study 2	P	OR (95% CI)	Study 3	P	OR (95% CI)
SNP
rs12778366a T>C	0.111/0.103	0.125/0.124	0.672	1.04 (0.86–1.26)	0.101/0.119	0.981	0.998 (0.84–1.18)
rs3740051a A>G	0.291/0.277	0.316/0.301	0.299	1.07 (0.94–1.22)	0.310/0.274	0.138	1.09 (0.97–1.23)
rs2236318a T>A	0.121/0.129	0.099/0.111	0.327	0.91 (0.75–1.10)	0.106/0.119	0.236	0.90 (0.76–1.07)
rs2236319 A>G	0.339/0.317	0.358/0.339	0.165	1.09 (0.96–1.24)	0.349/0.300	0.048	1.12 (1.00–1.26)
rs10823108 G>A	0.335/0.318	0.357/0.335	0.169	1.09 (0.96–1.24)	0.351/0.302	0.049	1.12 (1.00–1.26)
rs10997868a C>A	0.187/0.184	0.187/0.174	0.520	1.05 (0.90–1.23)	0.180/0.173	0.482	1.05 (0.91–1.21)
rs2273773 T>C	0.339/0.325	0.361/0.347	0.325	1.07 (0.94–1.21)	0.353/0.306	0.113	1.10 (0.98–1.23)
rs3818292 A>G	0.336/0.317	0.360/0.335	0.134	1.10 (0.97–1.25)	0.352/0.306	0.042	1.13 (1.00–1.26)
rs3818291 G>A	0.111/0.101	0.127/0.129	0.650	1.04 (0.87–1.26)	0.101/0.124	0.927	0.99 (0.84–1.17)
rs4746720a T>C	0.366/0.394	0.331/0.364	0.041	0.88 (0.77–0.99)	0.367/0.400	0.021	0.88 (0.78–0.98)
rs10823116a A>G	0.446/0.442	0.441/0.448	0.905	0.99 (0.88–1.12)	0.459/0.394	0.428	1.05 (0.94–1.16)
Haplotype
TGTGACCGGTG	0.294/0.279	0.316/0.300	0.250	1.08 (0.95–1.23)	0.315/0.273	0.095	1.10 (0.98–1.24)
TATAGCTAGCA	0.255/0.273	0.251/0.252	0.464	0.95 (0.83–1.09)	0.253/0.304	0.143	0.91 (0.81–1.03)
CATAGCTAATA	0.112/0.103	0.124/0.129	0.817	1.02 (0.85–1.23)	0.100/0.119	0.841	0.98 (0.83–1.16)
TAAAGATAGTA	0.123/0.128	0.104/0.112	0.484	0.94 (0.78–1.13)	0.105/0.122	0.319	0.92 (0.78–1.08)
TATAGCTAGCG	0.109/0.123	0.085/0.111	0.037	0.81 (0.67–0.99)	0.113/0.099	0.117	0.87 (0.73–1.03)
TATAGATAGTA	0.065/0.055	0.078/0.059	0.051	1.27 (0.998–1.61)	0.077/0.053	0.016	1.31 (1.05–1.62)
TATGACCGGTG	0.042/0.039	0.040/0.036	0.57	1.09 (0.81–1.48)	0.036/0.028	0.421	1.12 (0.85–1.48)

^aTag SNPs