Table 1.
Details of study protocol for the four prospective studies used in the meta-analysis of rs553668 and rs1085122
| Characteristic | WHII | BWHHS | ELSA | NPHSII |
|---|---|---|---|---|
| Study design | Prospective cohort | Prospective cohort | Prospective cohort | Prospective cohort |
| Sampling frame | Workplace | Across UK | Respondents of HSE | General practices |
| With DNA (n) | 5,500 | 3,443 | 5,274 | 2,775 |
| Genotyping method | IBC 50 k CVD chip and KASPar | IBC 50 k CVD chip and KASPar | KASPar | TaqMan |
| Men (%) | 77 | 0 | 48 | 100 |
| Follow-up (years) | 20 | 10 | 10 | 17 |
| Mean participant age (years) | 46 | 69 | 64 | 56 |
| Year of baseline survey | 1985–1988 | 1999–2001 | 1998, 1999, 2001 | 1989–1994 |
HSE, Health Survey for England; KASPar, KBioscience Competitive Allele–Specific PCR genotyping system