Table 3.
Genotype distribution and minor allele frequencies of rs553668 and rs1088522 in the four prospective studies used in the initial meta-analysis
| Variables per SNP | WHII | BWHHS | ELSA | NPHSII | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| rs553668 | Diabetes-free | Diabetes | p value | Diabetes-free | Diabetes | p value | Diabetes-free | Diabetes | p value | Diabetes-free | Diabetes | p value |
| GG | 2,971 (69) | 209 (62) | 2,198 (72) | 246 (73) | 3,570 (71.0) | 296 (68.5) | 1,773 (71.1) | 107 (68.6) | ||||
| GA | 1,221 (28) | 117 (35) | 0.02 | 809 (26) | 83 (25) | 0.65 | 1,327 (26.4) | 131 (30.3) | 0.055 | 656 (26.3) | 45 (28.9) | 0.78 |
| AA | 120 (3) | 13 (4) | 65 (2) | 9 (3) | 128 (2.6) | 5 (1.2) | 64 (2.6) | 4 (2.6) | ||||
| MAF | 0.17 | 0.21 | 0.006 | 0.15 | 0.15 | 0.81 | 0.16 | 0.16 | 0.66 | 0.16 | 0.17 | 0.55 |
| rs10885122 | ||||||||||||
| GG | 3,707 (77.4) | 285 (78.1) | 2,245 (76) | 273 (83) | 3,856 (76.8) | 316 (73.2) | 1,926 (77.0) | 114 (73.6) | ||||
| GT | 1,017 (21.2) | 77 (21.1) | 0.70 | 670 (23) | 49 (15) | 0.006 | 1,090 (21.7) | 114 (26.4) | 0.02 | 539 (21.5) | 38 (24.5) | 0.60 |
| TT | 64 (1.3) | 3 (0.8) | 54 (2) | 5 (2) | 75 (1.5) | 2 (0.5) | 37 (1.5) | 3 (1.9) | ||||
| MAF | 0.12 | 0.11 | 0.64 | 0.13 | 0.09 | 0.003 | 0.12 | 0.14 | 0.26 | 0.12 | 0.14 | 0.31 |
Distribution values are n (%)
MAF, minor allele frequency