Table 2.

Effect of hesperidin on the pharmacokinetic parameters of single-orally administrated pravastatin on rats.

Parameter	Control	Hespridin	Ratio
	(n = 6)	(n = 6)	(Hes/Cont)
Cmax (ng/mL)	116.5 ± 10.5	160.1 ± 20.7*	1.38
Tmax (min)	52.5 ± 8.2	52.5 ± 12.6	1.00
t1/2 (min)	69.1 ± 3.7	140.3 ± 30.8*	2.03
CL/f (L/hr)	111.2 ± 44.4	55.9 ± 37.5*	0.55
AUC (ng·hr/mL)	213.5 ± 21.1	319.3 ± 23.7*	1.47

The data are expressed as the mean ± S.D.

*P < .05, significantly different from control.