Table 4.
Inflammatory and epithelial changes in the airways and lungs following anti-IL-25 treatment in early life
| Experimental groups | |||
|---|---|---|---|
| Naive | Control | Anti-IL-25 | |
| Intrapulmonary eosinophils (OD450) | 0·06 (0·01) | 0·16 (0·04) | 0·31 (0·09)* |
| Intrapulmonary CD3+ T cells/mm2 | 3·6 (0·9) | 28·1 (3·2)*** | 28·7 (6·6)** |
| Lamina propria cells/100 µm basement membrane | 25·0 (1·3) | 38·4 (1·7)*** | 30·7 (1·5)* ## |
| Thickness of subepithelial collagen zone (µm) | 1·7 (0·1) | 4·3 (0·3)*** | 2·9 (0·1)* ## |
| Thickness of epithelial cell layer (µm) | 12·0 (0·4) | 16·8 (0·7)*** | 13·7 (0·8)## |
| Grade of goblet cell hyperplasia/metaplasia† | 0·0 (0·0) | 4·0 (2·0)*** | 2·0 (4·0)* |
Data are presented as mean ± standard error of the mean, except †which are median (interquartile range). Significant differences compared to naive animals shown as *P < 0·05, **P < 0·01 and ***P < 0·001, compared to control animals shown as ##P < 0·01. IL: interleukin.