Table 1.
Effects of essential oil (EO) of C. limon, morphine (MOR), and naloxone (NAL) on writhing induced by acetic acid.
| Treatment | Dose (mg/kg) | No. of writhings* | % inhibition |
|---|---|---|---|
| Vehicle | — | 14.6 ± 2.7 | — |
| EO | 50 | 3.7 ± 0.6a | 75 |
| EO | 100 | 3.6 ± 0.82a | 76 |
| EO | 150 | 2.9 ± 0.9a,b,c | 81 |
| EO plus NAL | 150 + 1.5 | 10.5 ± 1.7a,d | 27 |
| MOR | 5 | 1.6 ± 0.5a | 91 |
| MOR plus NAL | 5 + 1.5 | 11.2 ± 1.9e,f | 23 |
n = 7 per group.
*Values represent mean ± SEM.
a P < .01, significantly different from control, bP < .01, significantly different from EO 50 group, cP < .01, significantly different from EO 100 group. dP < .01, significantly different from EO 150 group, eP < .01, significantly different from EO plus NAL group, fP < .01, significantly different from MOR group. One-way ANOVA followed by Dunnett's test was applied to all data.