Table 8.
Expression Changes Specific for Ciprofloxacin or Novobiocin
| No. | Gene product | Fold change mRNA | |||
|---|---|---|---|---|---|
| Cipro 10 min | Novo 10 min | Cipro 60 min | Novo 60 min | ||
| Specific for Ciprofloxacin | |||||
| hi0020 | 2-Oxoglutarate/malate translocator | −2.0 | NC | −1.7 | NC |
| hl1135 | Phospho-N-acetylmuramoyl-pentapeptide-transferase | −2.2 | NC | −2.1 | NC |
| hl0070 | DNA repair protein RecN | 4.8 | NC | 13.0 | NC |
| hi0162 | Conserved hypothetical protein | 1.5 | NC | 1.8 | NC |
| hi0250 | Single-stranded DNA binding protein | 2.5 | NC | 2.9 | NC |
| hi0312 | Holliday junction DNA helicase | 1.8 | NC | 3.3 | NC |
| hi0600 | Recombinase RecA | 2.7 | NC | 2.0 | −1.8 |
| hi1159 | Conserved hypothetical protein | 1.5 | −3.5 | 3.0 | −1.8 |
| hi1188 | DNA helicase II | 1.9 | NC | 4.5 | NC |
| hi1546 | ImpA protein | 4.8 | NC | 15.0 | NC |
| Specific for Novobiocin | |||||
| hi0343 | Conserved hypothetical protein | NC | −2.7 | NC | −2.5 |
| hi0365 | Conserved hypothetical protein | NC | −4.4 | NC | −2.6 |
| hi0434 | Transformation protein | NC | −7.1 | NC | −4.3 |
| hi0440 | Penicillin-binding protein | NC | −2.2 | NC | −1.1 |
| hi0498 | Spermidine/putrescine-binding periplasmic protein precursor | NC | −2.4 | NC | −1.4 |
| hi0558 | Glucose-6-phosphate 1-dehydrogenase | NC | −2.3 | NC | −1.4 |
| hi0838 | Small protein a | NC | −2.8 | NC | −1.7 |
| hi0898 | Multidrug resistance protein | NC | −2.5 | NC | −1.5 |
| hi0983 | Conserved hypothetical protein | NC | −2.9 | NC | −1.9 |
| hi1151 | Conserved hypothetical protein | NC | −3.9 | NC | −2.8 |
| h1159 | Conserved hypothetical protein | NC | −3.5 | NC | −1.8 |
| hi1163 | D-Lactate dehydrogenase | NC | −3.2 | 3.6 | −2.5 |
| hi1190 | Conserved hypothetical protein | NC | −4.1 | NC | −9.8 |
| hi1191 | Conserved hypothetical protein | NC | −11.5 | NC | −17.3 |
| hi1388 | Anthranilate synthase component ii | NC | −3.3 | NC | 0.3 |
| hi1585 | Acetolactate synthase iii large chain | NC | −2.5 | NC | −1.4 |
| hi0037 | Rod shape-determining protein | NC | 2.0 | 1.7 | 1.8 |
| hi0690 | Glycerol uptake facilitator protein | NC | 1.6 | NC | 1.2 |
| hi0691 | Glycerol kinase | NC | 1.7 | NC | 1.4 |
| hi0971 | Acetyl-con carboxylase, biotin carboxyl carrier protein | NC | 1.7 | NC | 1.8 |
| hi1308 | Dihydrodipicolinate reductase | NC | 2.0 | NC | 1.9 |
| hi1623 | Mercury resistance regulatory protein | NC | 3.2 | NC | 3.2 |
| hi1659 | Ribonucleoside-diphosphate reductase, alpha chain | NC | 1.7 | 3.6 | 2.0 |
| hi1660 | Ribonucleoside diphosphate reductase, beta chain | NC | 2.3 | NC | 2.2 |
| hi1717 | Hypothetical protein | NC | 1.8 | NC | 1.9 |