Table 9.
Common Effects for Novobiocin or Ciprofloxacin
| Functional Groupa | Novobiocin | Ciprofloxacin | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Total no.of genes | Increased | % | Decreased | % | Increased | % | Decreased | % | |
| Amino acid biosynthesis | 70 | 5 | 7% | 29 | 41% | 2 | 3% | 16 | 23% |
| Aromatic amino acid family | 16 | 1 | 6% | 4 | 25% | 0% | 1 | 6% | |
| Aspartate family | 18 | 1 | 6% | 7 | 39% | 1 | 6% | 8 | 44% |
| Branched chain family | 10 | 0% | 5 | 50% | 0% | 0% | |||
| Glutamate family | 9 | 2 | 22% | 1 | 11% | 1 | 11% | 4 | 44% |
| Histidine family | 9 | 0% | 9 | 100% | 0% | 1 | 11% | ||
| Serine family and pyruvate family | 8 | 1 | 13% | 3 | 38% | 0% | 2 | 25% | |
| Biosynthesis of cofactors, prosthetic groups, and carriers | 56 | 5 | 9% | 16 | 29% | 0% | 2 | 4% | |
| Cell envelope | 79 | 12 | 15% | 11 | 14% | 2 | 3% | 5 | 6% |
| Cellular processes | 53 | 5 | 9% | 12 | 23% | 1 | 2% | 5 | 9% |
| Cell division | 17 | 3 | 18% | 6 | 35% | 0% | 0% | ||
| Chaperones | 6 | 0% | 2 | 33% | 0% | 2 | 33% | ||
| Others | 30 | 2 | 7% | 4 | 13% | 1 | 3% | 3 | 10% |
| Central intermediary metabolism | 30 | 1 | 3% | 12 | 40% | 0% | 7 | 23% | |
| Energy metabolism | 109 | 8 | 10% | 21 | 19% | 4 | 6% | 17 | 16% |
| Fatty acid and phospholipid metabolism | 26 | 11 | 42% | 5 | 19% | 2 | 8% | 2 | 8% |
| Hypothetical | 339 | 4 | 76% | 22 | 13% | 11 | 3% | 22 | 6% |
| Other categories | 95 | 7 | 7% | 14 | 15% | 1 | 1% | 5 | 5% |
| Purines, pyrimidines, nucleosides, and nucleotides | 52 | 6 | 12% | 5 | 10% | 1 | 2% | 5 | 10% |
| Regulatory functions | 68 | 6 | 9% | 11 | 16% | 2 | 3% | 8 | 12% |
| Replication, recombination, and DNA repair | 84 | 18 | 21% | 14 | 17% | 13 | 15% | 3 | 4% |
| Transcription | 26 | 4 | 15% | 4 | 15% | 3 | 12% | 1 | 4% |
| DNA-dependent RNA polymerase | 17 | 3 | 18% | 3 | 18% | 2 | 12% | 1 | 6% |
| Degradation of RNA | 9 | 1 | 11% | 1 | 11% | 1 | 11% | 0% | |
| Translation | 143 | 18 | 13% | 23 | 16% | 15 | 10% | 17 | 12% |
| Amino acyl tRNA synthetases | 34 | 9 | 26% | 4 | 12% | 6 | 18% | 3 | 9% |
| Ribosomal proteins synthesis and modification | 57 | 2 | 4% | 3 | 5% | 3 | 5% | 8 | 14% |
| Others | 52 | 7 | 13% | 16 | 31% | 6 | 12% | 6 | 12% |
| Transport and binding proteins | 123 | 10 | 8% | 31 | 25% | 2 | 2% | 19 | 15% |
| Amino acids peptides and amines | 38 | 3 | 8% | 12 | 32% | 0% | 8 | 21% | |
| Other transport and binding proteins | 85 | 7 | 8% | 19 | 11% | 2 | 2% | 11 | 13% |
| Total | 1353 | 132 | 10% | 284 | 21% | 62 | 5% | 134 | 10% |
a
As defined by Fleischmann et al. (1995).