Table 7.
Creatinine clearance grade 1 and 2 toxicities in patients treated with sitamaquine and amphotericin B for visceral leishmaniasis, Bihar, India
| Time point | Sitamaquine | Amphotericin B | ||||
|---|---|---|---|---|---|---|
| No. | Grade 1, no. (%) | Grade 2, no. (%) | No. | Grade 1, no. (%) | Grade 2, no. (%) | |
| Baseline | 41 | 3 (7) | 0 | 20 | 1 (5) | 0 |
| Day 5 | 41 | 4 (10) | 0 | 20 | 7 (35) | 2 (10) |
| Day 10 | 37 | 4 (11) | 0 | 19 | 5 (26) | 1 (5) |
| Day 16 | 40 | 2 (5) | 0 | 19 | 4 (21) | 1 (5) |
| Day 21 | 40 | 4 (10) | 0 | 16 | 5 (31) | 1 (6) |
| Day 26 | 40 | 1 (3) | 0 | 17 | 7 (41) | 0 |
| Day 30 | – | – | – | 18 | 3 (17) | 2 (11) |
| Day 58 | – | – | – | 19 | 1 (5) | 0 |
| Day 90 | 38 | 2 (5) | 0 | 19 | 2 (11) | 0 |
| Day 180 | 33 | 2 (6) | 0 | 18 | 0 | 0 |