Table 1.
Dexamethasone treatment induced dissemination of infective larvae to lungs, spleen, kidney, heart, liver, and brain in S. venezuelensis-infected mice
| Post-infection days | Organs | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Lungs | Spleen | Kidney | Heart | Liver | Brain | |||||||
| Inf + H2O | Inf + Dexa | Inf + H2O | Inf + Dexa | Inf + H2O | Inf + Dexa | Inf + H2O | Inf + Dexa | Inf + H2O | Inf + Dexa | Inf + H2O | Inf + Dexa | |
| 1 | 19 ± 4 | 17 ± 3 | 0 ± 0 | 20 ± 9* | 2 ± 1 | 14 ± 3* | 13 ± 6 | 16 ± 2 | 9 ± 4 | 38 ± 15* | 0 ± 0 | 5 ± 2* |
| 3 | 132 ± 14 | 203 ± 14* | 1 ± 1 | 4 ± 1* | 0 ± 0 | 1 ± 1 | 1 ± 1 | 2 ± 1 | 4 ± 1 | 5 ± 1 | 0 ± 0 | 2 ± 1 |
| 5 | 5 ± 2 | 8 ± 3 | 0 ± 0 | 2 ± 1* | 0 ± 0 | 2 ± 1* | 0 ± 0 | 62 ± 44* | 5 ± 1 | 57 ± 23* | 0 ± 0 | 0 ± 0 |
| 7 | 0 ± 0 | 14 ± 6* | 0 ± 0 | 2 ± 1* | 0 ± 0 | 8 ± 3* | 0 ± 0 | 1 ± 1 | 12 ± 10 | 57 ± 23* | 0 ± 0 | 1 ± 1 |
| 14 | 0 ± 0 | 13 ± 1* | 0 ± 0 | 23 ± 6* | 0 ± 0 | 6 ± 2* | 0 ± 0 | 3 ± 2 | 0 ± 0 | 19 ± 3* | 0 ± 0 | 3 ± 2* |
| 21 | 0 ± 0 | 16 ± 3* | 0 ± 0 | 18 ± 3* | 0 ± 0 | 13 ± 2* | 0 ± 0 | 20 ± 6* | 0 ± 0 | 10 ± 2* | 0 ± 0 | 3 ± 2* |
| 37 | 0 ± 0 | 13 ± 3* | 0 ± 0 | 2 ± 1 | 0 ± 0 | 3 ± 1 | 0 ± 0 | 5 ± 1* | 0 ± 0 | 2 ± 1 | 0 ± 0 | 3 ± 1* |
Organs were obtained on post-infection days 1, 3, 5, 7, 14, 21, and 37. To evaluate the number of infective larvae, the lungs, spleen, kidney, heart, liver, and brain were tweezed in saline and maintained at 27°C for 2 hours followed by centrifugation; the pellet was examined under light microscopy at 50× magnification for detection of parasites. Data are expressed as mean ± SEM of one representative experiment (N = 6). Inf = infected.
*
P < 0.05; Sv + H2O vs. Sv + Dexa.