Table 4.
Gene-level associations
| All Cases (N=445) | High-Grade Serous (N=262) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| PCA | Haplotype Analysis | PCA | Haplotype Analysis | |||||||
| Gene | Chr | N SNPs | N PC | p-value | N Haplotypes | p-value | N PC | p-value | N Haplotypes | p-value |
| GSTM1 | 1 | 1 | 1 | 0.65 | na | na | 1 | 0.73 | na | na |
| XPC | 3 | 11 | 5 | 0.52 | 7 | 0.63 | 5 | 0.92 | 7 | 0.80 |
| ABCB1 | 7 | 33 | 9 | 0.003 | 3 | 0.46 | 9 | 0.36 | 3 | 0.23 |
| CYP3A4 | 7 | 5 | 3 | 0.28 | 3 | 0.62 | 3 | 0.57 | 3 | 0.69 |
| CYP2C8 | 10 | 14 | 5 | 0.09 | 6 | 0.04 | 5 | 0.43 | 6 | 0.41 |
| XRCC1 | 19 | 16 | 4 | 0.37 | 6 | 0.50 | 4 | 0.44 | 5 | 0.54 |
| ERCC2 | 19 | 11 | 5 | 0.44 | 9 | 0.59 | 5 | 0.11 | 8 | 0.05 |
| ERCC1 | 19 | 3 | 2 | 0.37 | 3 | 0.30 | 2 | 0.12 | 3 | 0.07 |
Chr, chromosome; N cases, number of cases with no missing genotypes; N PC, number of principal components into which SNPs collapsed; bold indicates p < 0.05; sorted by gene set, then by chromosomal position.