Table 2.
Multivariate Cox regression model for predictors of progression to AIDS-defining event (ADE) or death since study entry among 1,712 HIV-infected patients
| Covariate | ADE (n=176c) | Death (n=176c) | AIDS or Death (n=296c) | |||
|---|---|---|---|---|---|---|
| Adjusted HR (95% CI) | P-value | Adjusted HR (95% CI) | P-value | Adjusted HR (95% CI) | P-value | |
| Drug use | ||||||
| Non- users | 1 (reference) | 1 (reference) | 1 (reference) | |||
| Non-injection drug users | 1.17 (0.84-1.63) | 0.35 | 1.30 (0.92-1.85) | 0.14 | 1.19 (0.92-1.56) | 0.08 |
| Injection drug usersa | 1.40 (0.90-2.17) | 0.14 | 2.38 (1.58-3.57) | <0.01 | 1.97 (1.43-2.70) | <0.01 |
| Male sex | 0.79 (0.55-1.14) | 0.21 | 0.72 (0.51-1.03) | 0.07 | 0.82 (0.62-1.09) | 0.17 |
| Age, per 10 years | 1.24 (1.05-1.47) | 0.01 | 1.54 (1.30-1.82) | <0.01 | 1.41 (1.24-1.61) | <0.01 |
| White race | 1.05 (0.77-1.43) | 0.76 | 0.76 (0.56-1.04) | 0.09 | 0.96 (0.76-1.23) | 0.77 |
| Prior ART (any vs. none) | 1.06 (0.69-1.64) | 0.79 | 1.08 (0.70-1.68) | 0.72 | 1.12 (0.80-1.56) | 0.51 |
| On HAART at study entry | 1.40 (0.87-2.26) | 0.16 | 1.18 (0.72-1.92) | 0.51 | 1.21 (0.83-1.75) | 0.32 |
| CD4 cell countsb, cells/mm3 | <0.01 | <0.01 | <0.01 | |||
| 100 | 1.51 (1.30-1.76) | 1.41 (1.22-1.63) | 1.46 (1.30-1.63) | |||
| 200 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| 350 | 0.57 (0.49-0.66) | 0.68 (0.58-0.78) | 0.63 (0.57-0.71) | |||
| 500 | 0.36 (0.27-0.48) | 0.56 (0.45-0.70) | 0.48 (0.40-0.57) | |||
| HIV-1 RNAb, log10 copies/mL (per one log increase) | 1.34 (1.11-1.63) | <0.01 | 1.27 (1.05-1.54) | 0.01 | 1.28 (1.10-1.48) | <0.01 |
HR=hazards ratio; CI=confidence interval; ART=antiretroviral therapy.
a
When comparing with non-injection drug users, HRs and CIs are as follows: 1.19 (0.78, 1.82), P=0.41; 1.83 (1.26, 2.65), P<0.01; 1.65 (1.23, 2.22), P<0.01.
b
The first values upon or after entry to the study.
c
Events for patients included in the final model.