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. Author manuscript; available in PMC: 2013 Feb 1.
Published in final edited form as: Neurobiol Aging. 2011 Feb 1;33(2):431.e1–431.e13. doi: 10.1016/j.neurobiolaging.2010.12.014

Figure 2.

Figure 2

Aging reduces the number of GABAergic interneurons in CA1. A. Aging was associated with a significant decrease in the number of GAD-67 immunoreactive cells in CA1 (n = 7), but no change in the number of NeuN-immunoreactive neurons (n = 7). The majority of NeuN immunoreactive neurons are pyramidal cells, suggesting that the number of pyramidal cells in CA1 did not change. B-D. Immunohistochemistry for GAD-67 labeling in area CA1 of young (B.) and aged (C.) rats revealed significant age-related decreases in inhibitory neurons in SO and SLM (D.). E-G. Immunohistochemistry for NeuN labeling in young (E.) and aged (F.) rats revealed a significant age-related decrease in total neuron number limited to SO (G.). Scale bar = 100 μm. *P < 0.05, **P < 0.01.