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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: J Immunol. 2011 May 13;186(12):7156–7163. doi: 10.4049/jimmunol.1002097

Figure 2. LIGHT signaling is not only essential but can also enhance LN hypertrophy.

Figure 2

A. WT mice were treated i.d. with HVEM-IgG and control IgG, immediately followed by CFA immunization i.d. at tail base. iLN cellularity was determined at day 3. P <0.05. Representative of two experiments. B. WT mice were treated i.d. with HVEM-IgG or control IgG, at day 0, 1, 2 of CFA immunization. iLN cellularity was determined at day 3. *, P <0.05, NS, not significant. Representative of two experiments. C. WT and HVEM−/−mice were immunized with CFA i.d. at tail base and iLN cellularity was determined at day 3. P <0.05. Representative of two experiments. D. WT mice were treated with Ad-null and Ad-LIGHT (5×1010 VP) i.d. at the tail base and iLN cellularity was determined at day 3. P <0.05. Representative of two experiments. E. LIGHT−/− mice were treated with Ad-null and Ad-LIGHT (5×1010 VP) i.d. at the tail base followed by CFA immunization. iLN cellularity was determined at day 3. *, P < 0.05, **, P < 0.01. Representative of two experiments.