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. Author manuscript; available in PMC: 2012 Jun 15.
Published in final edited form as: J Immunol. 2011 May 6;186(12):6905–6913. doi: 10.4049/jimmunol.1100274

Figure 3. Ovarian cancer-associated DCs co-express PD-1 and B7-H1 and accumulate in the ovarian cancer microenvironment.

Figure 3

Panel A shows histograms of tumor (T)-associated DCs (at day 47 following tumor challenge) and splenic DCs (Naïve), respectively, stained for PD-1. Inset numbers are relative mean fluorescence intensity. Cells were gated on CD11c. Panel B are confocal photomicrographs of purified CD11c cells directly stained in culture with anti-PD-1 (Red) and anti-B7-H1 antibodies, respectively. Panel C estimates the proportion of CD11+ cells and PD-1+ DCs (middle) amongst the infiltrating leukocytes at days 42, 47, and 61. Rightmost panel estimates the proportion of PD-1+ DCs as a percentage of total CD11c+ cells on the same days. Shown are the means (±s.e.m.) of 2–3 replicates. Panels are representative of 3 independent experiments.