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. 2011 May 11;12:229. doi: 10.1186/1471-2164-12-229

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Copyright ©2011 Vilardell et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Brain-related dosage effects. A) Venn diagram showing the overlap of the 324 significant genes with 623 genes identified by independent mouse studies related to brain phenotypes; B) RNA in situ hybridisations of BACH1 in postnatal mouse embryonic brain slices. C) In situ hybridisation of TTC3 in the same tissue. Images kindly provided by the HSA21 consortium ([4]; http://chr21.molgen.mpg.de/hsa21). D) Hierarchical clustering of 79 genes related to non-DS general brain disorders with the DS gene expression data sets. Clustering was performed with the J-Express 2009 software using Pearson correlation as similarity measure and complete linkage as update rule.