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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Exp Neurol. 2011 Feb 12;233(1):68–78. doi: 10.1016/j.expneurol.2011.02.004

Figure 1.

Figure 1

Diabetes-induced changes in neuroplasticity in the hippocampus, amygdala and prefrontal cortex in animal models. T1DM and T2DM rodents exhibit deficits in neuroplasticity in the prefrontal cortex (blue), hippocampus (red) or the amygdala (green). Neuroplasticity deficits may include electrophysiological deficits such as impairments in LTP, neuroanatomical alterations such as changes in dendritic morphology or neuronal spine density and alterations in neurochemical profiles. Ultimately, these changes may contribute to the development of cognitive-behavioral deficits diabetic animals. See text for details. Figure adapted from (Reznikov et al., 2009).