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. 2001 Mar;11(3):448–457. doi: 10.1101/gr.167601

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Copyright © 2001, Cold Spring Harbor Laboratory Press

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Hybridization of 20p12 BAC/PAC array (X-axis) using DNA extracted from CENP-A immunoprecipitated chromatin (bound) fractions from the patient (filled circles) and a normal (open square) lymphoblast cell line N2. Y-axis shows the percentage difference of the ratio of enhancement (R) of bound fractions over preimmunoprecipitation (input) fractions compared with a normal control cell line N1:
The BAC/PAC array covers ∼18 Mb of the 20p12 region of interest. Genome distances (Mb) for the 8-Mb region shown are measured relative to PAC dJ811H13. PAC dJ1009E24 and dJ905G11 map outside this region (indicated by the broken bars on the X-axis) and are 6.7 and 11.0 Mb from dJ811H13, respectively. The datapoint [mean ± standard error of mean (SEM) from eight experiments for the patient and four experiments for the normal N2] marks the midposition of each BAC/PAC. The four BAC/PACs that deviate significantly from the baseline values for surrounding BAC/PACs (P < 0.01) are listed next to the datapoint and indicated by an asterisk. The remaining BAC/PACs are listed on the top of the graph.

graphic file with name M1.gif — Hybridization of 20p12 BAC/PAC array (X-axis) using DNA extracted from CENP-A immunoprecipitated chromatin (bound) fractions from the patient (filled circles) and a normal (open square) lymphoblast cell line N2. Y-axis shows the percentage difference of the ratio of enhancement (R) of bound fractions over preimmunoprecipitation (input) fractions compared with a normal control cell line N1:
The BAC/PAC array covers ∼18 Mb of the 20p12 region of interest. Genome distances (Mb) for the 8-Mb region shown are measured relative to PAC dJ811H13. PAC dJ1009E24 and dJ905G11 map outside this region (indicated by the broken bars on the X-axis) and are 6.7 and 11.0 Mb from dJ811H13, respectively. The datapoint [mean ± standard error of mean (SEM) from eight experiments for the patient and four experiments for the normal N2] marks the midposition of each BAC/PAC. The four BAC/PACs that deviate significantly from the baseline values for surrounding BAC/PACs (P < 0.01) are listed next to the datapoint and indicated by an asterisk. The remaining BAC/PACs are listed on the top of the graph.