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Schematic representation of the cardiac sarcomere. The sarcomere is made up of thick (myosin) filaments (A-band) and thin (actin) filaments (I-band), which are interconnected by titin (with segments shown by colored bars on the top). The Z-line is the boundary between sarcomeres and the M-line is central portion of the A-band (Reprinted with permission from Ref 5. Copyright 2008 The Company of Biologists).
