Table 3.
Comparison of cystatin C, cathepsin L and S concentrations as predictors of lethal outcome among patients with peripheral artery disease.
| All-cause (n = 378) |
Cardiovascular mortality (n = 378) |
Non-cardiovascular mortality |
|
|---|---|---|---|
| HR for cystatin C (95% CI) | 4.91 (2.99–8.06) | 9.58 (4.61–19.91) | 2.99 (1.38–6.47) |
| Adjusted HR for cystatin C (95% CI)* | 2.47 (1.14–5.36) | 4.29 (1.26–14.6) | 1.60 (0.53–4.76) |
| HR for serum Cr (95% CI) | 1.02 (1.014–1.026) | 1.02 (1.01–1.03) | 1.01 (1.00–1.02) |
| Adjusted HR for Cr (95% CI)* | 1.00 (0.99–1.01) | 0.99 (0.98–1.01) | 1.00 (0.97–1.02) |
| HR for CrCl (95% CI)* | 0.97 (0.96–0.98) | 0.96 (0.94–0.97) | 0.98 (0.96–0.99) |
| Adjusted HR for CrCl (95% CI)* | 0.99 (0.97–1.01) | 0.98 (0.95–1.02) | 0.99 (0.95–1.02) |
| HR for cathepsin L (95% CI) | 1.03 (0.86–1.22) | 1.23 (0.94–1.60) | 0.90 (0.72–1.13) |
| Adjusted HR for cathepsin L (95% CI)* | 1.08 (0.89–1.32) | 1.40 (1.01–1.93) | 0.93 (0.73–1.19) |
| HR for cathepsin S (95% CI) | 0.99 (0.68–1.43) | 1.15 (0.72–1.85) | 0.82 (0.47–1.42) |
| Adjusted HR for cathepsin S (95% CI)* | 0.74 (0.47–1.16) | 0.90 (0.51–1.61) | 0.56 (0.29–1.07) |
*
Adjusted for age, gender, body mass index, smoking status, diabetes mellitus, ankle-brachial index, total cholesterol, prior myocardial infarct, pulse pressure, symptoms of leg ischemia, serum creatinine, creatinine clearance, and high-sensitivity C-reactive protein.