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. Author manuscript; available in PMC: 2011 Jun 8.
Published in final edited form as: Appl Microbiol Biotechnol. 2010 Apr 2;86(6):1719–1736. doi: 10.1007/s00253-010-2525-3

Fig. 13.

Fig. 13

Fungal PKS-NRPSs containing the Dieckman cyclase (DKC) releasing domain. a Two possible product release mechanisms in cAATrp (50) formation in the CPA (49) biosynthetic pathway. Dieckman cyclization/releasing (pathway A) and reductive releasing/cyclization/reoxidation (pathway B). b Major compounds isolated from A. oryzae M-2-3 transformed to express tenS (52–54) or to co-express tenS and orf3 (55). c Proposed biosynthesis and production of aspyridones (56 and 57) after activation of the regulator in apd gene cluster