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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: J Immunol. 2011 Apr 27;186(11):6585–6596. doi: 10.4049/jimmunol.1002794

Figure 4. Infection with an equivalent S. aureus dose leads to the establishment of catheter-related biofilm infection but rapid clearance from subcutaneous sites.

Figure 4

Wild type (WT), TLR2 knockout (KO), and TLR9 KO mice were infected with 5 × 105 CFU of USA300 LAC::lux either in the lumen of surgically implanted catheters (cath) to establish biofilm infection or subcutaneously (sc) in the absence of any indwelling device. Animals were sacrificed at the indicated days following S. aureus infection, whereupon host tissues surrounding infected catheters or s.c. injection sites were homogenized to quantitate bacterial burdens. Results are expressed as the number of CFU per mg host tissue to correct for differences in tissue sampling size. Significant differences in bacterial burdens between biofilm-infected versus s.c. injected mice are denoted by asterisks (*, p < 0.001).