Nonsense mutations and out of frame insertions and deletions are indicated as red arrows, while missense mutations are indicated as black arrows. Domains indicated include PHD, plant homeo domain finger, HMG, high mobility group box, FYRN, FY-rich N-terminal domain, FYRC, FY-rich C-terminal domain, SET, Su (var)3–9 Enhancer-of-zeste Trithorax methyltransferase domain.