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. 2001 Jul;11(7):1227–1236. doi: 10.1101/gr.165101

Table 1.

Top 25 Genes More Highly Expressed in AML Than in ALL

Gene description Probe Difference S.E. Z-score P-value1 Fold diff2 t-test3 t rank4 ut-test5 ut rank6 W. r.s.7 W rank8
Fumarylacetoacetate M55150 978.04 101.41 9.64 <0.0001 2.21 <0.0001 1 <0.0001 1 0.0146 2
Neuromedin B M21551 216.62 33.81 6.41 <0.0001 1.94 0.1952 64 0.0025 2 0.0432 7
Leukotriene C4 synthase U50136 1551.78 253.94 6.11 <0.0001 2.57 <0.0001 2 0.0082 4 0.0584 11
CDC25A Cell division  cycle 25A M81933 178.74 29.31 6.10 <0.0001 3.60 0.0510 38 0.0070 3 0.0678 14
Thrombospondin 1 U12471 128.52 21.94 5.86 <0.0001 1.83 0.0570 39 0.0145 5 0.3275 33
Zyxin X95735 2587.14 445.32 5.81 <0.0001 7.98 <0.0001 3 0.0199 6 0.0124 1
LYN V-yes-1 Yamaguchi  sarcoma viral related  oncogene homolog M16038 1337.77 231.45 5.78 <0.0001 4.49 <0.0001 4 0.0216 7 0.0503 10
Interferon-gamma  inducing factor  (IGIF) D49950 167.60 29.25 5.73 <0.0001 3.18 0.0004 7 0.0241 8 0.6428 50
ATP6C Vacuolar H+  ATPase proton  channel subunit M62762 1686.88 300.07 5.62 0.0001 2.33 0.0024 13 0.0322 9 0.4925 43
Metargidin U41767 481.47 86.18 5.59 0.0002 1.50 0.0049 19 0.0353 10 0.1220 16
Leptin receptor Y12670 859.65 154.73 5.56 0.0002 3.10 <0.0001 5 0.0414 12 0.0233 3
Ferritin, light  polypeptide M11147 7928.14 1428.69 5.55 0.0002 1.97 0.0799 44 0.0368 11 0.8361 55
HoxA9 U82759 602.71 110.33 5.46 0.0003 3.48 0.0017 12 0.0521 13 0.1409 18
NAB50 U63289 121.53 23.29 5.22 0.0013 n.a. 0.3464 79 0.0955 14 1.0000 >58
Calnexin D50310 1982.20 385.66 5.14 0.0019 1.47 0.6143 92 0.1184 15 1.0000 >58
PLCB2 Phospholipase  C, beta 2 M95678 1281.19 249.67 5.13 0.0020 1.97 0.0147 28 0.1347 16 0.4924 41
Polyadenylate binding  protein II Z48501 4474.14 879.99 5.08 0.0026 1.50 0.5856 90 0.1404 17 1.0000 >58
GTP-binding protein  (RAB31) U59877 398.95 79.87 5.00 0.0041 n.a. 1.0000 >105 0.1772 18 1.0000 >58
Chloride channel  (putative) 2163bp Z30644 760.30 154.08 4.93 0.0056 1.69 0.2998 76 0.2253 19 1.0000 >58
Proteogylcan 1,  secretory granule X17042 5188.71 1060.82 4.89 0.0070 3.82 0.0129 27 0.2738 20 0.8359 53
PPIase, mitochondrial M80254 377.99 77.41 4.88 0.0073 10.75 0.0015 10 0.2883 22 0.4925 42
CD33 M23197 579.93 119.10 4.87 0.0078 4.25 0.0002 6 0.3060 25 0.0503 9
Activated leucocyte  cell adhesion molecule L38608 119.96 24.71 4.85 0.0084 2.51 0.0488 37 0.2984 23 1.0000 >58
FCGR2B Fc fragment of  IgG, low affinity IIb,  receptor for (CD32) X62573 257.44 53.18 4.84 0.0090 1.47 1.0000 >105 0.2835 21 1.0000 >58
Interkeukin-8 Y00787 8645.98 1802.75 4.80 0.0112 9.63 0.0015 11 0.3032 24 0.2158 27

Dataset from Golub et al. (1999). 

1

P-value computed from Z-score using a modified Bonferroni's correction. 

2

(n.a.) The mean of one of the groups < = zero. 

3

P-value obtained from t-test with equivalent variances using a modified Bonferroni's correction. 

4

Relative ranking by significance values obtained from t-test with equivalent variances. >105 indicates that the gene was not ranked because the P-value was 1.0. 

5

P-value obtained from t-test with unequal variances using a modified Bonferroni's correction. 

6

Relative ranking by significance values obtained from t-test with unequal variances. 

7

P-value obtained from Wilcoxon rank sum using a modified Bonferroni's correction. 

8

Relative ranking by Wilcoxon significance values. >58 indicates that the gene was not ranked because the P-value was 1.0.