Figure 3.

Gene conversion tracts along psGBA. Positions at which both psGBA from chimpanzee and human differ and human GBA and psGBA are equal are considered possible gene conversion fragments from GBA to psGBA (light shading). The position following one of these blocks that was equal between both pseudogenes and different with the GBA gene (so that it interrupts the possible tract of gene conversion) is also indicated in the figure in lower case. Dark shadows indicate tracts where gene and pseudogene sequences are equal both in humans and in chimpanzees, but where orthologous sequences are different across species. Positions at which human psGBA, human GBA, and chimpanzee psGBA were different, or at which the GBA gene and psGBA in chimpanzee are equal and different from human psGBA, have not been taken into account. Variable sites found in the human pseudogene are represented in bold. (*) Similarity between genes and pseudogenes in position 1137 has to be taken with caution, because it is located after a single-nucleotide run of seven adenines, and the similarity could be a product of polymerase slippage and not of gene conversion. 1265i indicates the insertion after site 1265 in human psGBA.