Figure 10. Parkin is required for IPC.

A. WT and Parkin^−/− (KO) mice were subjected to sham treatment (CON) or IPC, followed by 20 min ischemia and 22 hr reperfusion. Area at risk was determined by Evan's blue injection after re-occlusion and showed no difference between groups. B. Infarct size was determined by TTC staining and reported as % of the area at risk. IPC reduced infarct size in WT mice but not in Parkin KO mice (*p<0.05, n = 6). Representative heart slices are shown.